ERCP and Hours of Sleep

Withdrawal expressed less than clonidine. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the heart and blood vessels. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. Hence, the excitation is transferred to the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM - glandule medulla), traditionally called the vasomotor center. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. Higher centers of the sympathetic nervous system located in the hypothalamus. As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. Weight of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases glandule release of the NORAD-renalina. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Pre-Preparata appointed interior. At glandule doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as here orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, glandule sexual function). Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood vessels (arteries and veins) glandule . Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. In accordance here this neurotropic antihypertensives share at the expense of the central and peripheral action. To lower blood pressure sympathetic glandule may be blocked at the level of: 1) sympathetic ganglia, 2) endings of postganglionic sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels. Guanetidin not penetrate through gematoentsefa-crystal barrier and does not alter the content catecholamines in the adrenal glands. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive glandule In this case, clonidine administered intravenously over 5-7 minutes, with the rapid introduction may in elevated blood pressure because of stimulation a2adrenoreceptors vessels. In sharp schenii discontinue the drug withdrawal glandule after 48 hours Means that block peripheral sympathetic innervation. Due to the blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases.